Important Research and Guidelines for Gender Affirming Treatment (GAT)

SPEKTRUM is proud to endorse the following research and resources for quality information, interpretation and statistics as they apply to Gender Affirming Treatment (GAT). All of our listed resources are vetted by our staff, advocates and/or board of directors.

Critical analysis of research is necessary to avoid misinformation or misinterpretation. Studies with approproiate sample size, structure, methods, and impact scores are required to provide professional guidance to healthcare providers, patients and their families.

Protocols and clinical guidelines must come from experienced bodies that have experience working with the population being studied or advised. 


This page was created in response to the widespread use of poor quality or outdated research, ill-advised opinion statements, and the establishment of data sites and sources claiming to be “experts” who may actually lack appropriate expertise to support the positive outcomes of communities in need. We encourage all individuals to consider at least 3 important variables when examining research (and prior to reading):

(1) WHO said it?

Do they have adequate training, experience and expertise?

(2) WHEN did they say it?

Is this research recent or does it represent outdated theories and concepts? Research is ALWAYS evolving.

(3) WHY did they say it?

Are the authors and researchers free from individual bias or commercial interest?

Young Man

Gender Affirming Treatment for Children & Adolescents

Gender Affirming Care and Young People (March 2022)

Fact sheet issued by the Department of Health & Human Services (DHHS)

Hormonal Treatment in Young People With Gender Dysphoria:
A Systematic Review (April 2018)

American Academy of Pediatrics

Ensuring Comprehensive Care and Support for Transgender and
Gender-Diverse Children and Adolescents (October 2018)

American Academy of Pediatrics

New Study Reveals Shocking Rates of Attempted Suicide Among
Trans Adolescents (September 2018)

Human Rights Campaign (HRC)

AMA to states: Stop interfering in health care of transgender children
(April 2021)

American Medical Association (AMA)

Critical Benefits of Familial and Community Support for Transgender Youth
(April 2021)

National Council on Family Relations (NCFR)

Advocacy for healthcare in LGBTQ+ populations

ANA Position Statement: Nursing Advocacy for LGBTQ+ Populations (November 2018)

American Nurses Association (ANA)

An Open Letter to Health, Education, Corporate, Government & Other Policy Leaders (March 2022)

National Academies of Science, Engineering and Medicine

Standards of Care for Gender Affirming Treatment (8) (*NEW, 2022)

World Professional Association for Transgender Health (WPATH)

A Model for Improving Health Care Quality for Transgender and Gender Nonconforming Patients

Academic Collaboration

Guidelines for the Primary and Gender-Affirming Care of
Transgender and Gender Nonbinary People

University of California SanFrancisco (UCSF)

Survey Finds Over Half of American Adults Would Support Their Teenager’s Request to Transition to Another Gender

American Osteopathic Association (AOA)

Update on Florida Boards of Medicine Forced Consent Forms and Class Action by Trans Adults against SB 254 (August 5, 2023)